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AIDS Educ Prev. 2009 Jun;21(3 Suppl):40-53. doi: 10.1521/aeap.2009.21.3_supp.40.

Impact of cigarette smoking on mortality in HIV-positive and HIV-negative veterans.

Author information

1
Department of Internal Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA. kristina.crothers@yale.edu

Abstract

It is unknown whether smoking confers similar mortality risk in HIV-positive as in HIV-negative patients. We compared overall mortality stratified by HIV and smoking of 1,034 HIV-positive block-matched to 739 HIV-negative veterans, enrolled 2001-2002 in the Veterans Aging Cohort 5 Site Study. Adjusted incidence rate ratios (IRR) for mortality were calculated using Poisson regression. Mortality was significantly increased in HIV-positive veterans according to both smoking status and pack-years in unadjusted and adjusted analyses (adjusted IRR 2.31, 95% confidence interval [CI] 1.53-3.49 for HIV-positive current smokers and IRR 1.32, 95% CI 0.67-2.61 for HIV-negative current smokers). Comorbid diseases were also significantly increased according to smoking status and pack-years. Current smoking is associated with poor outcomes; even lower levels of exposure appear to be detrimental in HIV-infected veterans. These findings support the need for improvements in smoking cessation and for studies of mechanisms and diseases underlying increased mortality in smokers with HIV.

PMID:
19537953
PMCID:
PMC3118467
DOI:
10.1521/aeap.2009.21.3_supp.40
[Indexed for MEDLINE]
Free PMC Article

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