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Kidney Int. 2009 Oct;76(7):700-4. doi: 10.1038/ki.2009.221. Epub 2009 Jun 17.

Hydrogen sulfide: a new EDRF.

Author information

1
Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada. rwang@lakeheadu.ca

Abstract

The first endothelium-derived relaxing factor (EDRF) ever identified is a gasotransmitter, nitric oxide (NO). Recent studies have provided several lines of evidence to support the premise that hydrogen sulfide (H(2)S), another gasotransmitter, is a new EDRF. H(2)S production is catalyzed in mammalian cells by cystathionine beta-synthase (CBS) and/or cystathionine gamma-lyase (CSE). The expression of CSE proteins and the activity of CBS have been observed in vascular endothelial cells. A measurable amount of H(2)S is produced from endothelium upon muscarinic cholinergic stimulation. The endothelium-dependent vasorelaxation induced by H(2)S shares many common mechanistic traits with those of endothelium-derived hyperpolarizing factor (EDHF). Deficiency in CSE expression increases blood pressure in CSE knockout mice and significantly diminishes endothelium-dependent relaxation of resistance arteries. More extensive and mechanistic studies in the future will help to determine whether H(2)S is a new EDRF or the very EDHF.

PMID:
19536086
DOI:
10.1038/ki.2009.221
[Indexed for MEDLINE]
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