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Kidney Int. 2009 Sep;76(5):492-9. doi: 10.1038/ki.2009.222. Epub 2009 Jun 17.

Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease.

Author information

1
Department of Medicine, Vanderbilt University Medical Center, C-3119A, MCN, 1161 21stAvenue, Nashville, TN 37232, USA. volker.haase@vanderbilt.edu

Abstract

Epithelial-to-mesenchymal transition (EMT) is a developmentally vital, molecularly complex cellular process by which epithelial cells lose apico-basal polarity and cell-cell contact, become motile, and acquire mesenchymal characteristics. Under pathophysiological conditions EMT has a central role in cancer progression and metastasis, and has been associated with fibrotic disorders. Microenvironmental changes such as alterations in oxygen levels and activation of hypoxic signaling through hypoxia-inducible factor (HIF) are emerging as important triggers and modulators of EMT. Recent insights into potential molecular mechanisms underlying oxygen-dependent regulation of this process and their relevance to disease are discussed.

PMID:
19536078
PMCID:
PMC3623274
DOI:
10.1038/ki.2009.222
[Indexed for MEDLINE]
Free PMC Article

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