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Genetics. 2009 Aug;182(4):1345-9. doi: 10.1534/genetics.109.105114. Epub 2009 Jun 17.

Variation in genomic recombination rates among heterogeneous stock mice.

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1
Laboratory of Genetics, University of Wisconsin, Madison, 53706, USA.

Abstract

We used a large panel of pedigreed, genetically admixed house mice to study patterns of recombination rate variation in a leading mammalian model system. We found considerable inter-individual differences in genomic recombination rates and documented a significant heritable component to this variation. These findings point to clear variation in recombination rate among common laboratory strains, a result that carries important implications for genetic analysis in the house mouse.

PMID:
19535547
PMCID:
PMC2728871
DOI:
10.1534/genetics.109.105114
[Indexed for MEDLINE]
Free PMC Article
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