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Semin Immunol. 2009 Aug;21(4):223-32. doi: 10.1016/j.smim.2009.05.009. Epub 2009 Jun 16.

The role of mitochondria in cellular defense against microbial infection.

Author information

1
INSERM U542, Hopital Paul Brousse, Batiment Lavoisier, Villejuif Cedex, France. Damien.arnoult@inserm.fr

Abstract

Mitochondria have been long recognized for their key role in the modulation of cell death pathways. Thus, it is therefore not surprising that this organelle represents a recurrent target for pathogenic microbes, aiming to manipulate the fate of the infected host cell. More recently, mitochondria have been shown to serve as a crucial platform for innate immune signaling, as illustrated by the identification of MAVS (also known as IPS-1, VISA and Cardif), NLRX1 and STING as mitochondrial proteins. This review discusses the tight interplay between microbial infection, innate immune signaling and mitochondria.

PMID:
19535268
DOI:
10.1016/j.smim.2009.05.009
[Indexed for MEDLINE]

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