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Curr Opin Cell Biol. 2009 Oct;21(5):623-9. doi: 10.1016/ Epub 2009 Jun 15.

Adhesion within the stem cell niches.

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Institut Curie, Centre National de la Recherche Scientifique UMR144, 26 rue d'Ulm, Paris Cedex 05, France.


Growing body of evidence confirms that cell-cell and cell-extracellular matrix adhesion within stem cell niches is essential for the establishment and maintenance of niche architecture, for the generation and transmission of short-distance regulatory signals, and for controlling the frequency and nature of stem cell divisions. Recent studies demonstrated that in many stem cell niches, adhesion to support cells and/or extracellular matrix determines orientation of stem cell division plane, thereby contributing to the control of stem cell self-renewal and differentiation. Thus, although further analysis of the implicated molecular mechanisms is required, cadherin-associated and integrin-associated events appear to play essential regulatory roles in tissue-specific stem cell niches.

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