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Sleep Breath. 2009 Nov;13(4):415-20. doi: 10.1007/s11325-009-0268-0. Epub 2009 Jun 17.

Diurnal variability of C-reactive protein in obstructive sleep apnea.

Author information

1
Department of Psychiatry, University of California, San Diego, La Jolla, 92093-0804, USA. pmills@ucsd.edu

Abstract

OBJECTIVE:

The objective of this study is to examine the diurnal variability of C-reactive protein (CRP) in obstructive sleep apnea (OSA).

METHODS AND MEASUREMENTS:

Participants included 44 women and men with untreated OSA (mean apnea/hypopnea index = 37.5, SD +/- 28) and 23 healthy adults with no OSA. Sleep was monitored with polysomnography in the University of California San Diego General Clinical Research Center. Over a 24-h period, blood was collected every 2 h, and CRP levels were determined.

RESULTS:

Adjusting for age, gender, and body mass index, a significant group by time interaction showed that patients with OSA had higher CRP levels during the daytime (8:00 a.m.-8:00 p.m.) versus the nighttime (10:00 p.m. until 6:00 p.m.; p < 0.001). Non-apneics showed no significant change in CRP levels during the 24 h.

CONCLUSIONS:

The findings indicate that sleep apnea patients have disproportionately elevated CRP levels in the day versus the nighttime, possibly as a result of carryover effects of nighttime arousal into the daytime.

PMID:
19533192
PMCID:
PMC2764070
DOI:
10.1007/s11325-009-0268-0
[Indexed for MEDLINE]
Free PMC Article

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