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Org Biomol Chem. 2009 Jul 7;7(13):2681-4. doi: 10.1039/b903635k. Epub 2009 May 5.

Preorganized macromolecular gene delivery systems: amphiphilic beta-cyclodextrin "click clusters".

Author information

1
Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, E-41092, Sevilla, Spain.

Abstract

Gene delivery systems based on the beta-cyclodextrin scaffold have been synthesized by combining the copper(I)-catalyzed azide-alkyne coupling ("click chemistry") and an efficient acylation method of the secondary hydroxyls; molecular flexibility, charge density and hydrophobic-hydrophilic balance are critical parameters that can be fine-tuned by the click approach.

PMID:
19532982
DOI:
10.1039/b903635k
[Indexed for MEDLINE]
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