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Kidney Int. 2009 Jul;76(1):10-2. doi: 10.1038/ki.2009.130.

Circulating TGF-beta1 as a reliable biomarker for chronic kidney disease progression in the African-American population.

Author information

1
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

Abstract

Progressive renal fibrosis is common to all chronic kidney diseases (CKD). Suthanthiran and colleagues identified a positive association between transforming growth factor-beta1 and several risk factors for CKD progression in African Americans but not in whites. This study offers a possible explanation for the higher prevalence of end-stage renal disease in African Americans and highlights the need for a better therapeutic strategy for this population.

PMID:
19528989
PMCID:
PMC4313549
DOI:
10.1038/ki.2009.130
[Indexed for MEDLINE]
Free PMC Article

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