Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cell Biol. 2009 Jun 15;185(6):935-7. doi: 10.1083/jcb.200905098.

The role of aneuploidy in promoting and suppressing tumors.

Author information

1
Department of Pharmacology, University of Wisconsin-Madison, Madison, WI 53562, USA. baweaver@wisc.edu

Abstract

Impaired mitotic checkpoint signaling can both promote and suppress tumors. The mitotic checkpoint targets Cdc20, the specificity factor of the ubiquitin ligase that promotes anaphase by targeting cyclin B and securin for destruction. In this issue, Li et al. (2009. J. Cell Biol. doi:10.1083/jcb.200904020) use gene replacement to produce mice expressing a Cdc20 mutant that cannot be inhibited by the mitotic checkpoint. In addition to the expected aneuploidy, these animals have a high tumor incidence that is likely caused by persistent aneuploidy coupled with nonmitotic functions of mutant Cdc20.

PMID:
19528293
PMCID:
PMC2711620
DOI:
10.1083/jcb.200905098
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center