Format

Send to

Choose Destination
Antimicrob Agents Chemother. 2009 Aug;53(8):3534-7. doi: 10.1128/AAC.01717-08. Epub 2009 Jun 15.

Pharmacokinetics and ex vivo pharmacodynamic antimalarial activity of dihydroartemisinin-piperaquine in patients with uncomplicated falciparum malaria in Vietnam.

Author information

1
Department of Infectious Diseases, Military Hospital 175, Ho Chi Minh City, Vietnam.

Abstract

Compared to healthy subjects, malaria patients show a reduction in the mean oral clearance (1.19 versus 5.87 liters/h/kg of body weight) and apparent volume of distribution (1.47 versus 8.02 liters/kg) of dihydroartemisinin in Vietnamese patients following treatment with dihydroartemisinin-piperaquine (Artekin) for uncomplicated Plasmodium falciparum. Dihydroartemisinin is responsible for most of the ex vivo antimalarial activity of dihydroartemisinin-piperaquine.

PMID:
19528277
PMCID:
PMC2715592
DOI:
10.1128/AAC.01717-08
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center