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Cell Host Microbe. 2009 Jun 18;5(6):593-601. doi: 10.1016/j.chom.2009.05.014.

Leading a sheltered life: intracellular pathogens and maintenance of vacuolar compartments.

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1
Center for Microbial Pathogenesis, Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.

Abstract

Many intracellular pathogens survive in vacuolar niches composed of host-derived membranes modified extensively by pathogen proteins and lipids. Although intracellular lifestyles offer protection from humoral immune responses, vacuole-bound pathogens nevertheless face powerful intracellular innate immune surveillance pathways that can trigger fusion with lysosomes, autophagy, and host cell death. Strategies used by vacuole-bound pathogens to invade and establish a replicative vacuole are well described, but how the integrity and stability of these parasitic vacuoles are maintained is poorly understood. Here, we identify potential mechanisms of pathogenic vacuole maintenance and the consequences of vacuole disruption by highlighting select bacterial and protozoan parasites.

PMID:
19527886
PMCID:
PMC2716004
DOI:
10.1016/j.chom.2009.05.014
[Indexed for MEDLINE]
Free PMC Article
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