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Cell Host Microbe. 2009 Jun 18;5(6):527-49. doi: 10.1016/j.chom.2009.05.016.

Autophagy, immunity, and microbial adaptations.

Author information

1
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA. vderetic@salud.unm.edu

Abstract

Autophagy adjusts cellular biomass and function in response to diverse stimuli, including infection. Autophagy plays specific roles in shaping immune system development, fueling host innate and adaptive immune responses, and directly controlling intracellular microbes as a cell-autonomous innate defense. As an evolutionary counterpoint, intracellular pathogens have evolved to block autophagic microbicidal defense and subvert host autophagic responses for their survival or growth. The ability of eukaryotic pathogens to deploy their own autophagic machinery may also contribute to microbial pathogenesis. Thus, a complex interplay between autophagy and microbial adaptations against autophagy governs the net outcome of host-microbe encounters.

PMID:
19527881
PMCID:
PMC2720763
DOI:
10.1016/j.chom.2009.05.016
[Indexed for MEDLINE]
Free PMC Article

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