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Biochim Biophys Acta. 2009 Oct;1790(10):980-96. doi: 10.1016/j.bbagen.2009.06.005. Epub 2009 Jun 13.

Protein aggregation as a paradigm of aging.

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  • 1INSERM U571, Paris Descartes University, Paris, F-75015, France.


The process of physiological decline leading to death of the individual is driven by the deteriorating capacity to withstand extrinsic and intrinsic hazards, resulting in damage accumulation with age. The dynamic changes with time of the network governing the outcome of misfolded proteins, exemplifying as intrinsic hazards, is considered here as a paradigm of aging. The main features of the network, namely, the non-linear increase of damage and the presence of amplifying feedback loops within the system are presented through a survey of the different components of the network and related cellular processes in aging and disease.

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