Format

Send to

Choose Destination
FEBS Lett. 2009 Jul 7;583(13):2213-7. doi: 10.1016/j.febslet.2009.06.018. Epub 2009 Jun 13.

Dexamethasone regulates expression of BRUCE/Apollon and the proliferation of neural progenitor cells.

Author information

1
Minerva Medical Research Institute, Biomedicum, Helsinki, Finland.

Abstract

Glucocorticoid hormones (GHs) regulate cell proliferation of neural progenitor cells (NPCs) contributing to reduction of neurogenesis after stress. We show here that dexamethasone (Dex) decreases BRUCE/Apollon (BRUCE) in cultured NPCs in a GH-receptor-dependent manner. Downregulation of BRUCE by Dex or using silencing RNA reduced the number of proliferating NPCs, whilst overexpression of BRUCE counteracted the effect of Dex. Dex also elevated the deubiquitinating enzyme, Usp8/Ubpy, which via Nrdp1 decreases BRUCE. The results show that BRUCE is a target for GHs in the NPCs, and that BRUCE controls cell division of NPCs and possibly of other stem cells.

PMID:
19527720
DOI:
10.1016/j.febslet.2009.06.018
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center