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J Med Imaging Radiat Oncol. 2009 Apr;53(2):234-9. doi: 10.1111/j.1754-9485.2009.02053.x.

Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein.

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  • 1Department of Radiation Oncology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of New South Wales, Kogarah, New South Wales, Australia.


Malignant myoepithelioma of the breast (MMB) is a rare and often aggressive disease with poor prognosis. Little is known regarding its optimal treatment and progression. We describe the clinical history of a woman following excision of a benign adenomyoepithelioma which recurred years later as a radioresistant malignant myoepithelioma with high levels of ataxia telangiectasia mutated protein and mutant p53 (Cys135Phe). MMB requires close follow-up and aggressive treatment. If adjuvant radiotherapy is adopted to improve local control, minimal postoperative delay and higher doses than for standard post-mastectomy radiation are recommended.

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