Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2009 Jun 12;137(6):1124-35. doi: 10.1016/j.cell.2009.03.025.

The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.

Author information

1
Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK.

Abstract

The Notch pathway is a highly conserved signaling system that controls a diversity of growth, differentiation, and patterning processes. In growing blood vessels, sprouting of endothelial tip cells is inhibited by Notch signaling, which is activated by binding of the Notch receptor to its ligand Delta-like 4 (Dll4). Here, we show that the Notch ligand Jagged1 is a potent proangiogenic regulator in mice that antagonizes Dll4-Notch signaling in cells expressing Fringe family glycosyltransferases. Upon glycosylation of Notch, Dll4-Notch signaling is enhanced, whereas Jagged1 has weak signaling capacity and competes with Dll4. Our findings establish that the equilibrium between two Notch ligands with distinct spatial expression patterns and opposing functional roles regulates angiogenesis, a mechanism that might also apply to other Notch-controlled biological processes.

PMID:
19524514
DOI:
10.1016/j.cell.2009.03.025
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center