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Cell. 2009 Jun 12;137(6):1001-4. doi: 10.1016/j.cell.2009.05.023.

p62 at the crossroads of autophagy, apoptosis, and cancer.

Author information

1
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. jorge.moscat@uc.edu

Abstract

The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.

PMID:
19524504
PMCID:
PMC3971861
DOI:
10.1016/j.cell.2009.05.023
[Indexed for MEDLINE]
Free PMC Article
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