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Cell. 2009 Jun 12;137(6):997-1000. doi: 10.1016/j.cell.2009.05.042.

Bridging physiology and pathology in AD.

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1
Howard Hughes Medical Institute, MIT Picower Institute for Learning and Memory, Cambridge, MA 02139, USA.

Abstract

The APP-processing pathway is a pathological component of Alzheimer's disease (AD), but there is no consensus regarding the physiological functions of APP and its products. Two studies (Nikolaev et al., 2009; Lauren et al., 2009) link the physiological and pathological aspects of APP processing. They show that the APP products, N-APP and Abeta42, are ligands for death receptor 6 and cellular prion protein, respectively, which are important in nervous system development and synaptic suppression.

PMID:
19524503
DOI:
10.1016/j.cell.2009.05.042
[Indexed for MEDLINE]
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