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Semin Immunol. 2009 Oct;21(5):265-72. doi: 10.1016/j.smim.2009.05.010. Epub 2009 Jun 12.

The role of CD40 and CD154/CD40L in dendritic cells.

Author information

1
Department of Immunology, 1959 NE Pacific Street, Health Sciences Building, Box 357650, Seattle, WA 98195-7650, USA.

Erratum in

  • Semin Immunol. 2010 Jun;22(3):190.

Abstract

In this review, we focus on the function of CD40-CD40L (CD154) interactions in the regulation of dendritic cell (DC)-T cell and DC-B cell crosstalk. In addition, we examine differences and similarities between the CD40 signaling pathway in DCs and other innate immune cell receptors, and how these pathways integrate DC functions. As research into DC vaccines and immunotherapies progresses, further understanding of CD40 and DC function will advance the applicability of DCs in immunotherapy for human diseases.

PMID:
19524453
PMCID:
PMC2749083
DOI:
10.1016/j.smim.2009.05.010
[Indexed for MEDLINE]
Free PMC Article

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