Send to

Choose Destination
See comment in PubMed Commons below
Eur J Intern Med. 2009 Jul;20(4):348-54. doi: 10.1016/j.ejim.2008.09.005. Epub 2008 Oct 19.

Vascular disease in rheumatoid arthritis: from subclinical lesions to cardiovascular risk.

Author information

  • 1Department of Internal Medicine, Colentina Clinical Hospital, Bucharest, Romania.


Rheumatoid arthritis (RA) is one of the most prevalent and complex inflammatory diseases affecting primarily the joints, but also associating several extra-articular features. The vascular disease in RA encompasses a large spectrum of lesions, from rheumatoid vasculitis to atherosclerotic lesions. During the last years the importance of the vascular disease related to atherosclerosis in terms of cardiovascular morbidity and global mortality became evident in RA. The inflammatory hypothesis of atherosclerosis in RA implies that mediators originating from the inflamed synovial tissue or from the liver may have systemic vascular consequences, leading to endothelial dysfunction and structural abnormalities of the vessels. Hence, the global management of patients with RA must include the improvement of cardiovascular risk in parallel with the management of joint disease.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center