Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2009 Aug 1;19(15):4183-90. doi: 10.1016/j.bmcl.2009.05.114. Epub 2009 Jun 2.

Discovery and functional evaluation of diverse novel human CB(1) receptor ligands.

Author information

1
Vernalis (R&D) Ltd, Granta Park, Abington, Cambridge, CB21 6GB, UK. n.foloppe@vernalis.com

Abstract

Ligand-based virtual screening with a 3D pharmacophore led to the discovery of 30 novel, diverse and drug-like ligands of the human cannabinoid receptor 1 (hCB(1)). The pharmacophore was validated with a hit rate of 16%, binding selectivity versus hCB(2), and expected functional profiles. The discovered compounds provide new tools for exploring cannabinoid pharmacology.

PMID:
19520572
DOI:
10.1016/j.bmcl.2009.05.114
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center