Send to

Choose Destination
See comment in PubMed Commons below
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Apr;79(4 Pt 1):041914. Epub 2009 Apr 15.

Nonlinear denoising of functional magnetic resonance imaging time series with wavelets.

Author information

Department of Epileptology, Neurophysics Group, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.


In functional magnetic resonance imaging (fMRI) the blood oxygenation level dependent (BOLD) effect is used to identify and delineate neuronal activity. The sensitivity of a fMRI-based detection of neuronal activation, however, strongly depends on the relative levels of signal and noise in the time series data, and a large number of different artifact and noise sources interfere with the weak signal changes of the BOLD response. Thus, noise reduction is important to allow an accurate estimation of single activation-related BOLD signals across brain regions. Techniques employed so far include filtering in the time or frequency domain which, however, does not take into account possible nonlinearities of the BOLD response. We here evaluate a previously proposed method for nonlinear denoising of short and transient signals, which combines the wavelet transform with techniques from nonlinear time series analysis. We adopt the method to the problem at hand and show that successful noise reduction and, more importantly, preservation of the shape of individual BOLD signals can be achieved even in the presence of in-band noise.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center