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PLoS One. 2009 Jun 11;4(6):e5880. doi: 10.1371/journal.pone.0005880.

Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling.

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1
Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Center, Utrecht, The Netherlands.

Abstract

Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/beta-catenin function results in unscheduled muscle progenitor proliferation, leading to slow and fast muscle hypertrophy accompanied by fast muscle degeneration. The effects of Wnt/beta-catenin signaling on fast muscle hypertrophy were rescued by misexpression of Myostatin or p21(CIP/WAF), establishing an in vivo regulation of myofibrillogenesis by Wnt/beta-catenin signaling and Myostatin. Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis.

PMID:
19517013
PMCID:
PMC2690692
DOI:
10.1371/journal.pone.0005880
[Indexed for MEDLINE]
Free PMC Article
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