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Med Sci Sports Exerc. 2009 Jul;41(7):1467-75. doi: 10.1249/MSS.0b013e318199491f.

Effects of quercetin and EGCG on mitochondrial biogenesis and immunity.

Author information

1
Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA. niemandc@appstate.edu

Abstract

PURPOSE:

To test the influence of 1000 mg of quercetin (Q) with or without 120 mg of epigallocatechin 3-gallate (EGCG), 400 mg of isoquercetin, and 400 mg of eicosapentaenoic acid and docosahexaenoic acid (Q-EGCG) on exercise performance, muscle mitochondrial biogenesis, and changes in measures of immunity and inflammation before and after a 3-d period of heavy exertion.

METHODS:

Trained cyclists (N = 39) were randomized to placebo (P), Q, or Q-EGCG and ingested supplements in a double-blinded fashion for 2 wk before, during, and 1 wk after a 3-d period in which subjects cycled for 3 h x d(-1) at approximately 57% Wmax. Blood, saliva, and muscle biopsy samples were collected before and after 2 wk of supplementation and immediately after the exercise bout on the third day. Blood and saliva samples were also collected 14 h after exercise.

RESULTS:

Two-week supplementation resulted in a significant increase in plasma quercetin for Q and Q-EGCG and granulocyte oxidative burst activity (GOBA) in Q-EGCG. Immediately after the third exercise bout, significant decreases for C-reactive protein (CRP), and plasma interleukin 6 (IL-6) and interleukin 10 (IL-10) were measured in Q-EGCG compared with P. Granulocyte colony-stimulating factor and CRP were reduced in Q-EGCG 14 h after exercise. No group differences were measured in muscle messenger RNA expression for peroxisome proliferator-activated receptor gamma coactivator alpha, citrate synthase, or cytochrome c.

CONCLUSIONS:

Two-week supplementation with Q-EGCG was effective in augmenting GOBA andin countering inflammation after 3 d of heavy exertion in trained cyclists.

PMID:
19516153
DOI:
10.1249/MSS.0b013e318199491f
[Indexed for MEDLINE]

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