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Bioorg Med Chem Lett. 2009 Aug 1;19(15):4217-22. doi: 10.1016/j.bmcl.2009.05.107. Epub 2009 May 30.

First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand.

Author information

1
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126 Milano, Italy.

Abstract

By combining in the same molecule Ras-interacting aromatic moieties and a sugar, we prepared a water-soluble Ras ligand that binds Ras and inhibits guanine nucleotide exchange. With this compound it was possible to determine experimentally by a (15)N-edited HSQC NMR experiment the ligand-Ras binding interface.

PMID:
19515561
DOI:
10.1016/j.bmcl.2009.05.107
[Indexed for MEDLINE]

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