We report the case of a single-eyed patient with acute occlusion of the central retinal artery on her functional eye. The patient was a 72-year-old women with high cardiovascular risk, bilateral severe myopia, and amblyopia in her right eye. The occlusion affected the left eye so treatment consisting of local intra-arterial fibrinolysis was initiated by administration of alteplase and sodic heparin in the left ophthalmic artery. The result was successful restoration of initial visual acuity after 1 month, which was stable at the 9-month-follow-up.