Abstract
A new series of water-soluble, mononaphthotrisulfobenzoporphyrazines, bearing an alkynyl side chain of varying lengths on the naphtho ring, were prepared and tested for their efficacy to inhibit plasma extravasation when used as photosensitizers during photodynamic therapy (PDT) of the retina in the rat. The hexynyl substituted photosensitizer was the most potent, and was able to produce complete inhibition, at low doses of photosensitizer and light.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Extravasation of Diagnostic and Therapeutic Materials / drug therapy
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Papilledema / blood
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Papilledema / drug therapy*
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Photochemotherapy
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / therapeutic use*
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Porphyrins / chemistry*
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Porphyrins / therapeutic use*
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Rats
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Solubility
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Structure-Activity Relationship
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Water / chemistry
Substances
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Photosensitizing Agents
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Porphyrins
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Water