Format

Send to

Choose Destination
See comment in PubMed Commons below
Methods Mol Biol. 2009;552:51-66. doi: 10.1007/978-1-60327-317-6_4.

An overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs.

Author information

1
PanTherapeutics, Lutry, Switzerland.

Abstract

G protein-coupled receptors (GPCRs) represent 50-60% of the current drug targets. There is no doubt that this family of membrane proteins plays a crucial role in drug discovery today. Classically, a number of drugs based on GPCRs have been developed for such different indications as cardiovascular, metabolic, neurodegenerative, psychiatric, and oncologic diseases. Owing to the restricted structural information on GPCRs, only limited exploration of structure-based drug design has been possible. Much effort has been dedicated to structural biology on GPCRs and very recently an X-ray structure of the beta2-adrenergic receptor was obtained. This breakthrough will certainly increase the efforts in structural biology on GPCRs and furthermore speed up and facilitate the drug discovery process.

PMID:
19513641
DOI:
10.1007/978-1-60327-317-6_4
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center