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Br J Cancer. 2009 Jul 7;101(1):27-31. doi: 10.1038/sj.bjc.6605124. Epub 2009 Jun 9.

Patients with usual vulvar intraepithelial neoplasia-related vulvar cancer have an increased risk of cervical abnormalities.

Author information

1
Department of Obstetrics and Gynaecology (791), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. R.deBie@obgyn.umcn.nl

Abstract

BACKGROUND:

Vulvar squamous cell carcinoma (SCC) originates the following two pathways, related to differentiated (d) vulvar intraepithelial neoplasia (VIN) or to human papillomavirus (HPV)-related usual (u) VIN. Multicentric HPV infections (cervix, vagina and vulva) are common. We hypothesise that patients with a uVIN-related vulvar SCC more often have cervical high-grade squamous intraepithelial lesions (HSILs) compared with women with dVIN-related vulvar SCC.

METHODS:

All vulvar SCCs (201) were classified to be dVIN- (n=164) or uVIN related (n=37). Data with regard to the smear history and cervical histology were retrieved from PALGA, the nationwide Netherlands database of histo- and cytopathology. For HSIL cervical smears of which histology was taken, HPV DNA analysis on both the vulvar and cervical specimens was performed.

RESULTS:

At least one smear was available in 145 (72%) of the 201 patients. Patients with a uVIN-related vulvar SCC more often had an HSIL compared with patients with a dVIN-related SCC (35 vs 2%, P<0.001). A total of 10 of the 13 HSILs were histologically assessed and identical HPV types were found in the vulva and cervix.

CONCLUSION:

These data emphasise the necessity to differentiate between dVIN- and uVIN-related vulvar tumours and to examine the entire lower female ano-genital tract once an uVIN-related lesion is found.

PMID:
19513077
PMCID:
PMC2713690
DOI:
10.1038/sj.bjc.6605124
[Indexed for MEDLINE]
Free PMC Article

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