Format

Send to

Choose Destination
Br J Cancer. 2009 Jul 7;101(1):1-6. doi: 10.1038/sj.bjc.6605126. Epub 2009 Jun 9.

Early diagnosis of oesophageal cancer.

Author information

1
MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge, UK.

Abstract

Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to chronic inflammation of differing aetiologies. Inflammation leads to somatically inherited genetic mutations altering control of the cell cycle, DNA replication and apoptosis, which together result in autonomous and uncontrolled proliferation. These cancers have often metastasised to lymph nodes and distant organs before symptomatic presentation and therefore carry a poor prognosis. It is therefore vital to diagnose oesophageal cancer at an early stage, before the development of symptoms, when treatment can dramatically improve prognosis. Understanding the pathogenesis of these cancers is vital to guide early diagnostic strategies.

PMID:
19513070
PMCID:
PMC2713695
DOI:
10.1038/sj.bjc.6605126
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center