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J Natl Cancer Inst. 2009 Jun 16;101(12):888-92. doi: 10.1093/jnci/djp114. Epub 2009 Jun 9.

Survivorship beyond convalescence: 48-month quality-of-life outcomes after treatment for localized prostate cancer.

Author information

1
Robert Wood Johnson Clinical Scholars Program, University of California, Los Angeles, 911 Broxton Avenue, Los Angeles, CA 90024, USA. jgore@mednet.ucla.edu

Abstract

Decision making for treatment of localized prostate cancer is often guided by therapeutic side-effect profiles. We sought to assess health-related quality-of-life outcomes for patients 48 months after treatment for localized prostate cancer. Men treated for localized prostate cancer (N = 475) were evaluated before treatment and at 11 intervals during the 48 months after intervention. Changes in mean health-related quality-of-life scores and the probability of regaining baseline levels of health-related quality of life were compared between treatment groups. All statistical tests were two-sided. Urinary incontinence was more common after prostatectomy (n = 307) than after brachytherapy (n = 90) or external beam radiation therapy (n = 78) (both P < .001), whereas voiding and storage urinary symptoms were more prevalent after brachytherapy than after prostatectomy (both P < .001). Sexual dysfunction profoundly affected all three treatment groups, with a lower likelihood of regaining baseline function after prostatectomy than after external beam radiation therapy or brachytherapy (P < .001). Bowel dysfunction was more common after either form of radiation therapy than after prostatectomy. These results may guide decision making for treatment selection and clinical management of patients with health-related quality-of-life impairments after treatment for localized prostate cancer.

PMID:
19509365
DOI:
10.1093/jnci/djp114
[Indexed for MEDLINE]

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