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Diabetes Care. 2009 Sep;32(9):1710-2. doi: 10.2337/dc09-0408. Epub 2009 Jun 9.

Increased left ventricular torsion in uncomplicated type 1 diabetic patients: the role of coronary microvascular function.

Author information

1
Department of Cardiovascular Medicine, University of Birmingham, Birmingham, UK. drgani23@gmail.com

Abstract

OBJECTIVE:

We used speckle tracking echocardiography to study the early changes in left ventricular (LV) torsion in young patients with uncomplicated type 1 diabetes and stress magnetic resonance imaging (MRI) to assess its interrelationships with coronary microangiopathy.

RESEARCH DESIGN AND METHODS:

We recruited 33 asymptomatic subjects with type 1 diabetes and 32 age-matched healthy control subjects. All subjects underwent echocardiograms. Stress MRIs were performed in 30 subjects (8 healthy control subjects) to compute myocardial perfusion reserve index (MPRI).

RESULTS:

A significant increase in LV torsion (2 +/- 0.7 vs. 1.4 +/- 0.7 degrees /cm, P < 0.05) was identified in longer-term and retinopathy-positive type 1 diabetic subjects (1.9 +/- 0.7 vs. 1.4 +/- 0.7 degrees /cm, P < 0.05) as compared with the healthy control subjects. The MPRI was independently associated with increased LV torsion.

CONCLUSIONS:

We demonstrate that LV torsion is increased in young patients with uncomplicated type 1 diabetes and that coronary microvascular disease may play a key pathophysiological role in the development of increased LV torsion.

PMID:
19509006
PMCID:
PMC2732135
DOI:
10.2337/dc09-0408
[Indexed for MEDLINE]
Free PMC Article

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