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Acta Haematol. 1991;86(1):46-8.

Recombinant human erythropoietin induced rapid healing of a chronic leg ulcer in a patient with sickle cell disease.

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Department of Medicine, College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia.


A 23-year-old man with severe sickle cell disease and a chronic non-healing left leg ulcer was entered into a study in which he received hydroxyurea (HU) and recombinant human erythropoietin (r-HuEPO) in order to modify the severity of his disease. HU 20 mg/kg/day effectively prevented vaso-occlusive crises and improved hematological parameters, but the chronic leg ulcer and chronic mild bone pains remained. Six months later, r-HuEPO 600-800 IU/kg subcutaneously was added at weekly intervals. This led to a rapid and complete healing of the chronic leg ulcer, further improvement in hematological parameters and relief from chronic pains. We conclude that treatment with r-HuEPO may provide an effective therapy for chronic leg ulcers in patients with sickle cell disease.

[Indexed for MEDLINE]

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