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Development. 2009 Jul;136(13):2141-51. doi: 10.1242/dev.033175.

Retinal horizontal cells: challenging paradigms of neural development and cancer biology.

Author information

1
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. poche@bcm.edu

Abstract

A group of retinal interneurons known as horizontal cells has recently been shown to exhibit a variety of unique biological properties, as compared with other nerve cells, that challenge many long-standing assumptions in the fields of neural development and cancer biology. These features include their unusual migratory behavior, their unique morphological plasticity, and their propensity to divide at a relatively late stage during development. Here, we review these novel features, discuss their relevance for other cell types, outline open questions in our understanding of horizontal cell development and consider their implications.

PMID:
19502480
PMCID:
PMC2729336
DOI:
10.1242/dev.033175
[Indexed for MEDLINE]
Free PMC Article

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