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Fertil Steril. 2009 Oct;92(4):1381-3. doi: 10.1016/j.fertnstert.2009.05.002. Epub 2009 Jun 6.

Genetic variation in the vitamin D receptor and polycystic ovary syndrome risk.

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Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran.


The possible association of vitamin D receptor gene FokI, BsmI, ApaI, and TaqI polymorphisms with polycystic ovary syndrome (PCOS) risk, and their influence on insulin resistance and serum levels of insulin in the women with PCOS was examined. The findings of the present study indicate that genetic variation in the vitamin D receptor may affect PCOS development as well as insulin resistance in women with PCOS.

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