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Vaccine. 1991 Sep;9(9):638-42.

The protective role of humoral neutralizing antibody in the NIH potency test for rabies vaccines.

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Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta, GA 30333.


Intraperitoneal vaccination of mice with rabies vaccine results in both dosage-dependent rabies virus neutralizing antibody titres and protection from lethal intracerebral (i.c.) challenge with fixed strain CVS rabies virus. Pre-exposure adoptive intravenous transfer of naive or immune cells did not significantly protect naive Balb/c mice from lethal i.c. CVS challenge, but immune serum and anti-rabies glycoprotein monoclonal antibodies (individually and in combination) did confer significant protection when administered before or up to 24 h after lethal i.c. rabies virus challenge.

[Indexed for MEDLINE]

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