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Cell Death Differ. 2010 Feb;17(2):215-20. doi: 10.1038/cdd.2009.69. Epub 2009 Jun 5.

miR-15a and miR-16-1 in cancer: discovery, function and future perspectives.

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1
The Lautenberg Center for General and Tumor Immunology, Hebrew University-Hadassah Medical School, Institute for Medical Research Israel-Canada, Ein Karem, P.O. Box 12272, Jerusalem 91120, Israel. aqeilan@cc.huji.ac.il

Abstract

MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and suppresses tumorigenicity both in vitro and in vivo. miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma. This review summarizes the discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL.

PMID:
19498445
DOI:
10.1038/cdd.2009.69
[Indexed for MEDLINE]
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