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Lab Chip. 2009 Jun 21;9(12):1676-80. doi: 10.1039/b901999e. Epub 2009 Apr 9.

Microfluidic chip for combinatorial mixing and screening of assays.

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  • 1University of Illinois at Urbana-Champaign, Chemical & Biomolecular Engineering, Urbana, IL 61801, USA.


This paper reports the design, fabrication and validation of a microfluidic well plate for combinatorial screening applications. Each well within the array is comprised of two 200 picoliter compartments that each contain a photonic crystal biosensor to enable the on-chip, in situ detection of (bio-) molecular binding events. This microfluidic chip utilizes arrays of Actuate-to-Open valves to isolate all compartments, which allows the chip to be decoupled from pneumatic control lines and thus to be transported freely between filling, sensing and characterization platforms. A proof-of-principle 4 x 4 protein/antibody binding assay was performed to demonstrate the discrete mixing and on-chip sensing capabilities.

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