Format

Send to

Choose Destination
Pigment Cell Melanoma Res. 2009 Aug;22(4):400-19. doi: 10.1111/j.1755-148X.2009.00585.x. Epub 2009 May 28.

The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma.

Author information

1
Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.

Abstract

Melanocytes undergo extensive genetic changes during transformation into aggressive melanomas. These changes deregulate genes whose aberrant activity promotes the development of this disease. The phosphoinositide-3-kinase (PI3K) and mitogen-activated protein (MAP) kinase pathways are two key signaling cascades that have been found to play prominent roles in melanoma development. These pathways relay extra-cellular signals via an ordered series of consecutive phosphorylation events from cell surface throughout the cytoplasm and nucleus regulating diverse cellular processes including proliferation, survival, invasion and angiogenesis. It is generally accepted that therapeutic agents would need to target these two pathways to be an effective therapy for the long-term treatment of advanced-stage melanoma patients. This review provides an overview of the PI3 kinase pathway focusing specifically on two members of the pathway, called PTEN and Akt3, which play important roles in melanoma development. Mechanisms leading to deregulation of these two proteins and therapeutic implications of targeting this signaling cascade to treat melanoma are detailed in this review.

PMID:
19493313
PMCID:
PMC3610526
DOI:
10.1111/j.1755-148X.2009.00585.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center