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J Perinat Med. 2009;37(5):561-4. doi: 10.1515/JPM.2009.100.

Effect of exogenous surfactant therapy on levels of pulmonary surfactant proteins A and D in preterm infants with respiratory distress syndrome.

Author information

1
Department of Pediatrics, College of Medicine, Kyunghee University, Kangdong-Gu, Seoul, Korea.

Abstract

OBJECTIVES:

To examine whether exogenous pulmonary surfactants (exPS) substitute for or merely supplement endogenous pulmonary surfactants (enPS) by looking at sequential changes in the surfactant proteins (SP) SP-A and SP-D in alveolar pools.

METHODS:

Fourteen preterm infants with RDS treated with an artificial surfactant were compared to five normal-term infants without RDS who were treated with artificial ventilation at birth.

RESULTS:

Immediately after birth, SP-A and SP-D were essentially absent in the alveolar pools of the RDS group, but were present at normal levels in the controls. Treatment with exPS apparently stimulated enPS production.

CONCLUSIONS:

In infants who responded well to exPS therapy, the SP concentration reached essentially normal levels within 48-72 h after birth.

PMID:
19492923
DOI:
10.1515/JPM.2009.100
[Indexed for MEDLINE]

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