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Cell Metab. 2009 Jun;9(6):485-7. doi: 10.1016/j.cmet.2009.05.007.

Metformin and insulin meet in a most atypical way.

Author information

1
Howard Hughes Medical Institute, Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. morris.white@childrens.harvard.edu

Abstract

A recent Cell paper by He et al. (2009) shows how metformin circumvents a block between insulin and atypical protein kinase C in obese and diabetic mice to inhibit gluconeogenesis by stimulating the phosphorylation of CBP and the disassembly of the CREB transcriptional complex.

PMID:
19490902
DOI:
10.1016/j.cmet.2009.05.007
[Indexed for MEDLINE]
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