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Cephalalgia. 2010 Jan;30(1):17-26. doi: 10.1111/j.1468-2982.2009.01892.x.

The abnormal recovery cycle of somatosensory evoked potential components in children with migraine can be reversed by topiramate.

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Headache Centre, Neurology Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Catholic University, Rome, Italy.


The aim of this study was to compare the recovery cycle of somatosensory evoked potentials (SEPs) in children with migraine without aura before and after treatment with topiramate. Eleven migraine children were studied before and after a 3-month treatment with topiramate at the average dose of 1.3 mg/kg/day. We calculated the SEP latency and amplitude modifications after paired electrical stimuli at 5, 20 and 40 ms interstimulus intervals, comparing them with a single stimulus condition assumed as baseline. In nine patients, who had a significant reduction in headache frequency after treatment, the recovery cycles of the P24 (P = 0.03) and N30 (P < 0.005) potentials were longer after than before topiramate treatment. In two migraineurs who did not show any improvement, the recovery cycles of the cortical SEP components were even shorter after treatment. Our results suggest that topiramate efficacy in paediatric migraine prophylaxis is probably related to restored cortical excitability.

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