Send to

Choose Destination
Acta Paediatr. 2009 Sep;98(9):1487-93. doi: 10.1111/j.1651-2227.2009.01365.x. Epub 2009 Jun 1.

Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys.

Author information

Laboratory of Exercise Biology (BAPS), Blaise Pascal University, Bat Biologie B, Aubière, France.



We investigate the effects of a 2-month weight-loss programme on plasma levels of adiponectin, leptin and resistin in obese adolescent boys.


Twenty-one obese adolescent boys (BMI = 30.8 +/- 3.2 kg/m(2)) completed the weight-loss programme including: 1/ either energy restriction (R), 2/ or individualized exercise training at the point of maximum lipid oxidation (Lipox(max)) (E), 3/ or energy restriction and training (RE). Body composition, lipid oxidation and plasma levels of adiponectin, leptin and resistin were measured before and after intervention.


Following the weight-loss programme, adolescents of the RE group showed an improvement of their body composition (p < 0.01), an increase in plasma adiponectin (+73.7%, p < 0.01) and a decrease in plasma leptin (-38.8%, p < 0.01) leading to an increase in adiponectine/leptin ratio (ALR, +144.4%, p < 0.01) higher than the R or E groups. E and RE groups only showed a similar significant increase in plasma resistin (p < 0.05) and a significant improvement of lipid oxidation rate at Lipox(max) (p < 0.01 and p < 0.001). In addition, in RE group, ALR is correlated with waist/hip and waist/height ratios, resistin level, homoeostasis mode assessment (HOMA-IR) index and Lipox(max).


In obese adolescents boys, moderate exercise training completed at Lipox(max) and combined with energy restriction improves their ability to oxidize lipids, which is associated with a normalization of their adiponectin, leptin and resistin levels resulting in an improved insulin sensitivity, as attested by a higher ALR and a lower HOMA-IR.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center