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South Med J. 2009 Jul;102(7):765-8. doi: 10.1097/SMJ.0b013e3181a8d1e4.

The lack of vitamin D toxicity with megadose of daily ergocalciferol (D2) therapy: a case report and literature review.

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  • 1Department of Endocrinology, Mountain Home VAMC, Mountain Home, TN , USA.

Abstract

The maximum daily dose of vitamin D currently recommended is 2000 IU. Ergocalciferol (D2) 50,000 IU orally weekly for 8-12 weeks is often used to treat vitamin D deficient patients (25(OH) vitamin D <20 ng/mL). The lack of vitamin D toxicity after massive doses of ergocalciferol has yet to be reported in the literature. We report a case of a 56-year-old woman who received supratherapeutic doses of ergocalciferol (150,000 IU orally daily) for 28 years without toxicity. We discuss the possible mechanisms which may account for a lack of toxicity despite intake of massive daily doses of ergocalciferol in this patient.

PMID:
19488004
DOI:
10.1097/SMJ.0b013e3181a8d1e4
[PubMed - indexed for MEDLINE]
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