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Crit Care Med. 2009 Jul;37(7):2210-5. doi: 10.1097/CCM.0b013e3181a0321b.

Are there sex-based differences in serum troponin I after cardiac surgery?

Author information

1
Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain. 8936ard@comb.es

Abstract

OBJECTIVE:

To determine whether there are sex-based differences in serum troponin I (TnI) after cardiac surgery with cardiopulmonary bypass.

DESIGN:

Prospective, observational, cohort study.

SETTING:

Tertiary cardiac surgery intensive care unit (ICU) at a university hospital.

INTERVENTIONS:

None.

MEASUREMENTS AND MAIN RESULTS:

Serum TnI was measured in samples obtained at ICU admission and 6, 12, 24, and 48 hours later. A total of 761 consecutive patients were studied (444 men and 317 women). The characteristics and results of the different sex subgroups were as follows:A) Coronary bypass: 165 men and 38 women. Age, Parsonnet score, Acute Physiology and Chronic Health Evaluation III score, prevalence of renal failure, intra-aortic balloon use, and the lengths of cardiopulmonary bypass, mechanical ventilation, and ICU stay were similar in the two groups. Body mass index, red-cell transfusion needs, and use of noradrenaline were significantly higher in women, whereas dobutamine requirements were higher in men. Mortality: 3 men (1.6%) vs. 0 women (p = not significant).The TnI peak was slightly, but significantly, higher in men (6.2 +/- 4.9 vs. 4.5 +/- 2.6 microg/L. p < 0.05).B) Valve surgery: 279 men and 279 women. Some significant differences were found: Women were older than men and had higher Parsonnet score and transfusion needs. The other recorded variables were similar. Mitral prosthesis: 62 men and 125 women (p < 0.05). Mitral valvuloplasty: 24 men, 7 women (p < 0.05). Aortic prosthesis: 162 men, 103 women (p < 0.05). Mitral and aortic prosthesis: 31 men and 44 women (p < 0.05). TnI peaks were similar for both sexes in each valve subgroup. Mortality: 3 men (1%) vs. 11 women (3.4%) (p < 0.05).The TnI peak did not reach any significant differences between sexes (men 7.9 +/- 6.0 vs. 8.5 +/- 6.5 microg/L in women. p = not significant).

CONCLUSION:

No clinically relevant sex-based differences were found in the TnI peaks after cardiac surgery.

PMID:
19487939
DOI:
10.1097/CCM.0b013e3181a0321b
[Indexed for MEDLINE]

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