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Crit Care Med. 2009 Jul;37(7):2235-41. doi: 10.1097/CCM.0b013e3181a55273.

Protective effects of adenosine A2A receptor agonist in ventilator-induced lung injury in rats.

Author information

1
Department of Intensive Care Medicine and Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.

Abstract

OBJECTIVES:

Mechanical ventilation is associated with overwhelming inflammatory responses that are associated with ventilator-induced lung injury (VILI) in patients with acute respiratory distress syndrome. The activation of adenosine A2A receptors has been reported to attenuate inflammatory cascades.

HYPOTHESIS:

The administration of A2A receptors agonist ameliorates VILI.

METHODS:

Rats were subjected to hemorrhagic shock and resuscitation as a first hit to induce systemic inflammation. The animals randomly received the selective A2A receptor agonist CGS-21680 or a vehicle control in a blinded fashion at the onset of resuscitation phase. They were then randomized to receive mechanical ventilation as a second hit with a high tidal volume of 20 mL/kg and zero positive end-expiratory pressure, or a low tidal volume of 6 mL/kg with positive end-expiratory pressure of 5 cm H2O.

RESULTS:

The administration of CGS-21680 attenuated lung injury as evidenced by a decrease in respiratory elastance, lung edema, lung injury scores, neutrophil recruitment in the lung, and production of inflammatory cytokines, compared with the vehicle-treated animals.

CONCLUSIONS:

The selective A2A receptor agonist may have a place as a novel therapeutic approach in reducing VILI.

PMID:
19487932
PMCID:
PMC3951985
DOI:
10.1097/CCM.0b013e3181a55273
[Indexed for MEDLINE]
Free PMC Article

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