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J Clin Invest. 2009 Jun;119(6):1438-49. doi: 10.1172/JCI38019. Epub 2009 Jun 1.

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.

Author information

1
Instituto de Neurociencias (CSIC-UMH), San Juan de Alicante, Spain.

Abstract

The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition (EMT). Throughout evolution, the capacity of cells to switch between these two cellular states has been fundamental in the generation of complex body patterns. Here, we review the EMT events that build the embryo and further discuss two prototypical processes governed by EMT in amniotes: gastrulation and neural crest formation. Cells undergo EMT to migrate and colonize distant territories. Not surprisingly, this is also the mechanism used by cancer cells to disperse throughout the body.

PMID:
19487820
PMCID:
PMC2689100
DOI:
10.1172/JCI38019
[Indexed for MEDLINE]
Free PMC Article

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