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Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9815-9. doi: 10.1073/pnas.0903369106. Epub 2009 Jun 1.

Targeting atherosclerosis by using modular, multifunctional micelles.

Author information

1
Vascular Mapping Center, Burnham Institute for Medical Research, University of California, Santa Barbara, 3119 Biology II Building, CA 93106-9610, USA.

Abstract

Subtle clotting that occurs on the luminal surface of atherosclerotic plaques presents a novel target for nanoparticle-based diagnostics and therapeutics. We have developed modular multifunctional micelles that contain a targeting element, a fluorophore, and, when desired, a drug component in the same particle. Targeting atherosclerotic plaques in ApoE-null mice fed a high-fat diet was accomplished with the pentapeptide cysteine-arginine-glutamic acid-lysine-alanine, which binds to clotted plasma proteins. The fluorescent micelles bind to the entire surface of the plaque, and notably, concentrate at the shoulders of the plaque, a location that is prone to rupture. We also show that the targeted micelles deliver an increased concentration of the anticoagulant drug hirulog to the plaque compared with untargeted micelles.

PMID:
19487682
PMCID:
PMC2689312
DOI:
10.1073/pnas.0903369106
[Indexed for MEDLINE]
Free PMC Article
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