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Cancer Res. 2009 Jun 1;69(11):4555-8. doi: 10.1158/0008-5472.CAN-09-0142.

Aurora-A and hBora join the game of Polo.

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1
Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Utrecht, The Netherlands.

Abstract

Overactivation of both Polo-like kinase-1 (Plk1) and Aurora-A is linked to cancer development, and small-molecule inhibitors that target these kinases are currently tested as anticancer drugs. Here, we discuss recent advances in the understanding of the functional crosstalk between Plk1 and Aurora-A before and during mitosis. Several recent findings have led to a better appreciation of how the activities of these distinct mitotic kinases are intertwined. Such insight is important for the expected utility of small-molecule inhibitors targeting Plk1 or Aurora-A, and it might help us to improve their application.

PMID:
19487276
DOI:
10.1158/0008-5472.CAN-09-0142
[Indexed for MEDLINE]
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